Makoto Fujiwara Selected Research

Alkaline Phosphatase

12/2021	Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling.
12/2020	Potential pathological role of single nucleotide polymorphism (c.787T>C) in alkaline phosphatase (ALPL) for the phenotypes of hypophosphatasia.
1/2020	Clinical Practice Guidelines for Hypophosphatasia.
4/2019	Adult hypophosphatasia with compound heterozygous p.Phe327Leu missense and c.1559delT frameshift mutations in tissue-nonspecific alkaline phosphatase gene: a case report.
1/2013	Treatment of Hypophosphatemic Rickets with Phosphate and Active Vitamin D in Japan: A Questionnaire-based Survey.

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Makoto Fujiwara Research Topics

Disease

3	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 12/2021 - 01/2013
3	Osteogenesis Imperfecta (Lobstein Disease) 01/2021 - 09/2011
3	Hypophosphatasia 12/2020 - 04/2019
3	Neoplasms (Cancer) 11/2020 - 04/2016
3	Bone Diseases (Bone Disease) 01/2020 - 06/2014
2	Rickets (Rachitis) 12/2021 - 01/2014
2	Hypophosphatemia 12/2021 - 01/2013
2	Lung Neoplasms (Lung Cancer) 11/2020 - 01/2019
2	Metabolic Bone Diseases (Osteopenia) 04/2019 - 04/2016
2	Allan-Herndon-Dudley syndrome 01/2019 - 08/2012
2	Hypophosphatemic Rickets 01/2014 - 01/2013
2	Bone Resorption 10/2012 - 09/2011
1	Familial Hypophosphatemia (Phosphate Diabetes) 12/2021
1	Metabolic Diseases (Metabolic Disease) 12/2020
1	Margins of Excision 11/2020
1	Lymphatic Metastasis 11/2020
1	Chronic Renal Insufficiency 05/2020
1	Adult Hypophosphatasia 04/2019
1	Choriocarcinoma 01/2019
1	Hypersensitivity (Allergy) 01/2019
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019
1	Insulin Resistance 01/2019
1	Anaphylaxis (Anaphylactic Shock) 01/2019
1	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 01/2019
1	Sarcoma (Soft Tissue Sarcoma) 04/2016
1	Hypoxia (Hypoxemia) 04/2016
1	Congenital Cortical Hyperostosis (Infantile Cortical Hyperostosis) 06/2014
1	Vitamin D Deficiency 01/2014
1	Hypercalciuria 01/2013
1	Secondary Hyperparathyroidism 01/2013
1	Achondroplasia 10/2012
1	Scoliosis 01/2012

Drug/Important Bio-Agent (IBA)

5	Alkaline PhosphataseIBA 12/2021 - 01/2013
2	Fibroblast Growth Factor-23IBA 12/2021 - 01/2014
2	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 12/2020 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 05/2020 - 01/2019
2	Thyroid HormonesIBA 01/2019 - 08/2012
2	Vitamin D FDA LinkGeneric 01/2014 - 01/2013
1	PHEX Phosphate Regulating Neutral EndopeptidaseIBA 12/2021
1	ZincIBA 12/2021
1	Collagen Type I (Type I Collagen)IBA 01/2021
1	4-phenylbutyric acid (Buphenyl)FDA Link 01/2021
1	CreatinineIBA 05/2020
1	phosphorylethanolamine (phosphoethanolamine)IBA 04/2019
1	Neutralizing AntibodiesIBA 01/2019
1	metreleptinIBA 01/2019
1	AntibodiesIBA 01/2019
1	LeptinIBA 01/2019
1	Triglycerides (Triacylglycerol)IBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 04/2016
1	Pharmaceutical PreparationsIBA 04/2016
1	CatecholaminesIBA 04/2016
1	Parathyroid Hormone (Parathormone)IBA 04/2016
1	Dinoprostone (PGE2)FDA Link 04/2016
1	CytokinesIBA 06/2014
1	alpha2 Subunit Collagen Type IIBA 06/2014
1	Phosphates (Orthophosphate)IBA 01/2013
1	Growth Hormone (Somatotropin)IBA 10/2012
1	MineralsIBA 10/2012
1	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 10/2012
1	Diphosphonates (Bisphosphonates)IBA 10/2012
1	atrial natriuretic factor receptor CIBA 01/2012
1	Natriuretic PeptidesIBA 01/2012
1	Pamidronate (Aredia)FDA LinkGeneric 09/2011

Therapy/Procedure

2	Segmental Mastectomy (Lumpectomy) 11/2020 - 01/2019
1	Therapeutics 06/2014
1	Intravenous Infusions 09/2011